Prof. Satyanarayan Pattnaik
Talla Padmavathi College of Pharmacy, India
Title: Mesoporous Silica Molecular Sieve Based Nanocarriers in Drug Dissolution Research
Abstract:
With the increasingly
hydrophobic nature of the candidate drugs, solubility and dissolution rates
have become the limiting factors that affect bioavailability of oral and
parenteral formulations. In this scenario mesoporous silica nanocarriers
present an attractive platform for improvement of dissolution of poorly soluble
drugs. The strategies in this technology essentially involve nano-amorphous or
nano-crystalline confinement of drugs in the mesopores of silica substrates. It
is known that nanonization improves drug dissolution velocity by offering a
larger effective surface area. Furthermore, though physically unstable,
amorphization is also an interesting method for dissolution enhancement.
Molecular rearrangement of drug candidate is prevented in the mesopores of drug
loaded mesoporous silica nanoparticles resulting in stable amorphous state of
the drug.
Current research in this area is focused
on investigating the factors influencing the drug release from these carriers,
the kinetics of drug release and manufacturing approaches to scale-up
production for commercial manufacture. This presentation provides an overview
of different methods adopted for synthesis of mesoporous materials, influence
of processing factors on properties of these materials and drug loading
methods. The drug release kinetics from mesoporous silica systems, the
manufacturability and stability of these formulations. Finally, the safety and
biocompatibility issues related to these silica based materials will be
discussed.
Biography:
Dr.
Satyanarayan Pattnaik, is a post-graduate in pharmaceutical sciences and
has earned his doctorate degree in Pharmacy from Berhampur University in the
year 2010. Having teaching, research and professional experience of about 20
years, Dr. Pattnaik is currently serving as Professor and Head, Department of Pharmaceutics
at Talla Padmavathi College of Pharmacy, Warangal, INDIA. Actively engaged in
research since past twelve years, he has about 30 internationally acclaimed publications
in reputed peer reviewed journals with an impressive h-index and citations. He
has about 40 articles abstracted in various national and international seminars
and conferences, 01 patent and 02 books and three book chapters to his credit.
His areas of research interest include Pharmaceutical nanotechnology, Pharmaceutical
formulation development, controlled drug delivery, Pharmaceutical material
science including micro and mesoporous materials in drug delivery,
Solublization techniques, etc. Being
Associate Editor, editorial board member and reviewer for many reputed
international journals, he is serving to the research community since past
decade. He is a widely visited scientist as invited speaker/keynote speaker at
various conferences and seminars contributing to the growth of pharmaceutical
sciences. He is member of reputed national and international professional
bodies like Indian Pharmaceutical Association (IPA), Association of Pharmaceutical
Teachers of India (APTI), International Society for Pharmacoeconomics and
Outcomes Research (ISPOR), Athens Institute for Education and Research (ATINER),
etc.